ADS Capstone Chronicles Revised

‭16‬

‭correlation‬ ‭significant‬ ‭correlations‬‭were‬‭found‬‭(Figure‬‭9),‬‭signaling‬ ‭that‬ ‭relationships‬ ‭in‬ ‭the‬ ‭data‬ ‭are‬‭non-linear.‬ ‭All‬ ‭numerical‬ ‭variable‬ ‭distributions‬ ‭are‬ ‭skewed.‬ ‭Table‬ ‭2‬ ‭shows‬ ‭the‬ ‭variables’‬ ‭median,‬ ‭mean,‬ ‭standard‬ ‭deviation,‬ ‭interquartile range, and skew value.‬ ‭Table 2‬ ‭Numerical Variable Descriptives‬ ‭Xn‬ ‭x̃‬ ‭x̅‬ ‭s‬ ‭IQR‬ ‭Skew‬ ‭Age‬ ‭61.0‬ ‭55.8‬ ‭21.8‬ ‭43-72‬ ‭-0.78‬ ‭Price‬ ‭0.17‬ ‭18.53‬ ‭172.33‬ ‭.05-.64‬ ‭12.08‬ ‭Weight‬ ‭70‬ ‭73.8‬ ‭22.07‬ ‭62-89‬ ‭0.28‬ ‭Manu‬ ‭1‬ ‭7.53‬ ‭40.28‬ ‭1-50‬ ‭10.31‬ ‭matrix;‬ ‭no‬

‭Figure 9‬ ‭Correlation Matrix‬

‭4.5.3‬ ‭Categorical‬ ‭Input‬ ‭features.‬ ‭Nominal‬ ‭distributions‬ ‭were‬ ‭examined‬ ‭with‬‭respect‬‭to‬ ‭the‬ ‭outcome‬ ‭variable.‬ ‭Nominal‬ ‭features‬ ‭include‬ ‭expedited,‬ ‭report_source‬ ‭(doctor,‬ ‭pharmacist,‬ ‭other‬ ‭healthcare‬ ‭professional),‬ ‭company,‬ ‭country,‬ ‭and‬ ‭sex.‬ ‭Color‬ ‭coded,‬ ‭proportional‬ ‭bar‬ ‭charts‬ ‭were‬ ‭created‬ ‭to‬ ‭assess‬ ‭differences‬ ‭in‬ ‭category‬ ‭frequencies.‬ ‭Frequency‬ ‭counts‬ ‭and‬ ‭proportions‬ ‭for‬ ‭each‬ ‭variable‬ ‭level‬ ‭were‬ ‭calculated‬ ‭with‬ ‭df[‘variable’].value_counts‬‭(Table‬‭3).‬‭Figure‬ ‭10‬ ‭shows‬ ‭the‬ ‭relationship‬ ‭between‬ ‭output‬ ‭and‬ ‭report‬ ‭source,‬ ‭where‬ ‭physicians‬ ‭and‬ ‭doctors‬ ‭are‬ ‭less‬ ‭likely‬ ‭to‬ ‭report‬ ‭deaths‬ ‭compared‬ ‭to‬ ‭other‬ ‭healthcare‬ ‭professionals,‬ ‭even‬‭though‬‭they‬‭both‬‭make‬‭up‬‭the‬‭majority‬ ‭of‬ ‭the‬ ‭sample.‬ ‭The‬ ‭sample‬ ‭contains‬ ‭10%‬ ‭more‬ ‭females‬ ‭than‬ ‭males‬ ‭and‬ ‭most‬ ‭reports‬ ‭come‬ ‭from‬ ‭the‬ ‭US.‬ ‭Most‬‭reports‬‭in‬‭FAERS‬ ‭are‬ ‭expedited,‬ ‭meaning‬ ‭that‬ ‭they‬ ‭contain‬ ‭serious,‬ ‭unexpected‬ ‭ADRs‬ ‭that‬ ‭must‬ ‭be‬ ‭reported within 15 days.‬ ‭Table 3‬ ‭Categorical Variables‬ ‭Xn‬ ‭k‬ ‭Mode‬ ‭p̂‬

‭Figure 8‬ ‭Age, Weight, Sex, and Outcome‬ ‭A‬

‭B‬

‭Sex‬

‭2 (F/M)‬

‭Female‬

‭55.1%‬

‭Source‬

‭3 (D,P,O)‬

‭Doctor‬

‭48.7%, 41.6%‬

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